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The Blue Fugates


Special Appreciation
Some of the lineage information for
this "Blue Fugates" page
was found in files at genealogy sites such as
Genforum.com, the LDS site, Rootsweb.com, etc..
Your generosity and help is very much appreciated.

Particular Appreciation
is for information provided by researcher
A very special THANK YOU, MARY, for such
patient work and selfless sharing.
Mary has helped with hundreds of genealogy inquiries
through her detailed entries in the
"Fugate Family Genealogy Forum"
of "Genforum" at Genealogy.com
(clicking on will open a separate browser window)

Only PORTIONS and certainly NOT ALL of
the information shown on this webpage were provided by
and/or documented by and/or approved by Mary.

~Smith-Fugate Connections~

Descendants of
Richard &Nancy Alicia "Lissie"(Combs) Smith
married into assorted Fugate families,
some with descendants of
Martin &Sarah(LNU) Fugate
others with descendants of
John &Sarah(McCarty) Fugate
The relationship between
this Martin Fugate and this John Fugate

Martin was a son of Josias &Mary(Martin) Fugate.
Josias's ancestry is unproven/unknown.
John's ancestry is unproven/unknown,
but he is NOT a son of Josias & Mary.

Further down this page is an article
from "Science 82," of November, 1982, by Cathy Trost, entitled
"The Blue People of Troublesome Creek"
The story of an Appalachian malady,
an inquisitive doctor, and a paradoxical cure.

The story centers around newly-born
    The following is the lineage down to Benjy:

  • Generation #1
    Josias Fugate
    b: 1680
    m: Mary Martin
    b: 1692
    • Generation #2
      Martin Fugate
      b: 1725 VA
      m: Sarah LNU
      b: 1726 VA
      • Generation #3
        William Fugate
        b: 1765 VA
        m: Sarah "Jane" Stevens
        b: 1766 VA
        • Generation #4
          Levi Fugate
          b: 1795 KY
          m: Haney Noble
          b: 1790 KY
          • Generation #5
            People of this generation and onward
            are named in the article further below.

            Martin Fugate
            b: 1828
            m: Elizabeth "Betsy" Smith
            daughter of Richard &Nancy Alicia "Lissie"(Combs) Smith
            b: 1823
            • Generation #6
              Levi Fugate
              b: 1844
              m: Mahala "Cricket" Ritchie
              b: 1854
              daughter of James &Hannah(Fugate) Ritchie
              granddaughter of Martin &Mary(Wells) Fugate
              g-granddaughter of Benjamin &Hannah(Devers) Fugate
              gg-granddaughter of Martin &Sarah(LNU) Fugate
              • Generation #7
                Luna Fugate
                b: 1887
                m: John C. Stacy
                b: 1886
                son of Shadrack Elsberry &Polly Ann(Mullins) Stacy
                • Generation #8
                  • Generation #9
                    Alva Stacy
                    m: Hilda Godsey
                    • Generation #10
                      Benjy Stacy

The story of an Appalachian malady,
an inquisitive doctor, and a paradoxical cure.

~ by Cathy Trost
©Science 82, November, 1982

Six generations after a French orphan named Martin Fugate settled on the banks of
eastern Kentucky's Troublesome Creek with his redheaded American bride,
his great-great-great great grandson was born in a modern hospital
not far from where the creek still runs.

The boy inherited his father's lankiness
and his mother's slightly nasal way of speaking.

What he got from Martin Fugate was dark blue skin.
"It was almost purple," his father recalls.

Doctors were so astonished by the color of Benjy Stacy's skin that
they raced him by ambulance from the maternity ward in the hospital near Hazard to
a medical clinic in Lexington. Two days of tests produced no explanation for
skin the color of a bruised plum.

A transfusion was being prepared when Benjy's grandmother spoke up.
"Have you ever heard of the blue Fugates of Troublesome Creek?"
she asked the doctors.

"My grandmother Luna on my dad's side was a blue Fugate.
It was real bad in her," Alva Stacy, the boy's father, explained.
"The doctors finally came to the conclusion that Benjy's color
was due to blood inherited from generations back."

Benjy lost his blue tint within a few weeks,
and now he is about as normal looking a seven-year-old boy as you could hope to find.
His lips and fingernails still turn a shade of purple-blue when he gets cold or angry
a quirk that so intrigued medical students after Benjy's birth that they would crowd
around the baby and try to make him cry. "Benjy was a pretty big item in the hospital,"
his mother says with a grin.

Dark blue lips and fingernails are the only traces of Martin Fugate's legacy left
in the boy; that, and the recessive gene that has shaded many of the Fugates and
their kin blue for the past 162 years.

They're known simply as the "blue people" in the hills and hollows
around Troublesome and Ball Creeks. Most lived to their 80s and 90s
without serious illness associated with the skin discoloration.
For some, though, there was a pain not seen in lab tests.
That was the pain of being blue in a world that is
mostly shades of white to black.

There was always speculation in the hollows about what made the blue people blue:
heart disease, a lung disorder, the possibility proposed by one old-timer that
"their blood is just a little closer to their skin." But no one knew for sure,
and doctors rarely paid visits to the remote creekside settlements where most of
the "blue Fugates" lived until well into the 1950s. By the time a young hematologist
from the University of Kentucky came down to Troublesome Creek in the 1960s to cure
the blue people, Martin Fugate's descendants had multiplied their recessive genes
all over the Cumberland Plateau.

Madison Cawein began hearing rumors about the blue people when he went to work at
the University of Kentucky's Lexington medical clinic in 1960. "I'm a hematologist,
so something like that perks up my ears," Cawein says, sipping on whiskey sours and
letting his mind slip back to the summer he spent "tromping around the hills
looking for blue people."

Cawein is no stranger to eccentricities of the body. He helped isolate an antidote
for cholera, and he did some of the early work on L-dopa, the drug for Parkinson's
disease. But his first love, which he developed as an Army medical technician in
World War II, was hematology. "Blood cells always looked so beautiful to me," he says.

Cawein would drive back and forth between Lexington and Hazard an eight-hour ordeal
before the tollway was built and scour the hills looking for the blue people he'd
heard rumors about. The American Heart Association had a clinic in Hazard, and it
was there that Cawein met "a great big nurse" who offered to help.

Her name was Ruth Pendergrass, and she had been trying to stir up medical interest
in the blue people ever since a dark blue woman walked into the county health department
one bitterly cold afternoon and asked for a blood test.

"She had been out in the cold and she was just blue!"
recalls Pendergrass, who is now 69 and retired from nursing.
"Her face and her fingernails were almost indigo blue. It like to scared
me to death! She looked like she was having a heart attack. I just knew
that patient was going to die right there in the health department
but she wasn't a'tall alarmed. She told me that her family was the blue Combses who
lived up on Ball Creek. She was a sister to one of the Fugate women." About this
same time, another of the blue Combses, named Luke, had taken his sick wife up to
the clinic at Lexington. One look at Luke was enough to "get those doctors down here
in a hurry," says Pendergrass, who joined Cawein to look for more blue people.

Trudging up and down the hollows, fending off "the two mean dogs that everyone had
in their front yard," the doctor and the nurse would spot someone at the top of a
hill who looked blue and take off in wild pursuit. By the time they'd get to the
top, the person would be gone. Finally, one day when the frustrated doctor was idling
inside the Hazard clinic, [siblings] Patrick and Rachel Ritchie walked in.

"They were bluer'n hell," Cawein says.
"Well, as you can imagine, I really examined them.
After concluding that there was no evidence of heart disease, I said 'Aha!'
I started asking them questions: 'Do you have any relatives who are blue?'
then I sat down and we began to chart the family."

Cawein remembers the pain that showed
on the Ritchie brother's and sister's faces.
"They were really embarrassed about being blue,"
he said. "Patrick was all hunched down in the hall.
Rachel was leaning against the wall. They wouldn't come into the waiting room.
You could tell how much it bothered them to be blue."

After ruling out heart and lung diseases, the doctor suspected methemoglobinemia,
a rare hereditary blood disorder that results from excess levels of methemoglobin
in the blood. Methemoglobin which is blue, is a nonfunctional form of the red
hemoglobin that carries oxygen. It is the color of oxygen-depleted blood seen
in the blue veins just below the skin.

If the blue people did have methemoglobinemia, the next step was to find out the
cause. It can be brought on by several things: abnormal hemoglobin formation,
an enzyme deficiency, and taking too much of certain drugs, including vitamin K,
which is essential for blood clotting and is abundant in pork liver and vegetable oil.

Cawein drew "lots of blood" from the Ritchies and hurried back to his lab. He tested
first for abnormal hemoglobin, but the results were negative.

Stumped, the doctor turned to the medical literature for a clue. He found references
to methemoglobinemia dating to the turn of the century, but it wasn't until he came
across E. M. Scott's 1960 report in the Journal of Clinical Investigation
(vol. 39, 1960) that the answer began to emerge.

Scott was a Public Health Service doctor at the Arctic Health Research Center in
Anchorage who had discovered hereditary methemoglobinemia among Alaskan Eskimos and
Indians. It was caused, Scott speculated, by an absence of the enzyme diaphorase
from their red blood cells. In normal people hemoglobin is converted to methemoglobin
at a very slow rate. If this conversion continued, all the body's hemoglobin would
eventually be rendered useless. Normally diaphorase converts methemoglobin back to
hemoglobin. Scott also concluded that the condition was inherited as a simple
recessive trait. In other words, to get the disorder, a person would have to inherit
two genes for it, one from each parent. Somebody with only one gene would not have
the condition but could pass the gene to a child.

Scott's Alaskans seemed to match Cawein's blue people. If the condition were
inherited as a recessive trait, it would appear most often in an inbred line.

Cawein needed fresh blood to do an enzyme assay. He had to drive eight hours back
to Hazard to search out the Ritchies, who lived in a tapped-out mining town called
Hardburly. They took the doctor to see their uncle, who was blue, too. While in the
hills, Cawein drove over to see Zach (Big Man) Fugate, the 76-year-old patriarch
of the clan on Troublesome Creek. His car gave out on the dirt road to Zach's house,
and the doctor had to borrow a Jeep from a filling station.

Zach took the doctor even farther up Copperhead Hollow to see his Aunt Bessie Fugate,
who was blue. Bessie had an iron pot of clothes boiling in her front yard, but she
graciously allowed the doctor to draw some of her blood.

"So I brought back the new blood and set up my enzyme assay," Cawein continued.
"And by God, they didn't have the enzyme diaphorase. I looked at other enzymes and
nothing was wrong with them. So I knew we had the defect defined.''

Just like the Alaskans, their blood had accumulated so much of the blue molecule
that it over- whelmed the red of normal hcmoglobin that shows through as pink in
the skin of most Caucasians.

Once he had the enzyme deficiency isolated, methylene blue sprang to Cawein's mind
as the "perfectly obvious" antidote. Some of the blue people thought the doctor was
slightly addled for suggesting that a blue dye could turn them pink. But Cawein knew
from earlier studies that the body has an alternative method of converting
methemoglobin back to normal. Activating it requires adding to the blood a substance
that acts as an "electron donor." Many substances do this, but Cawein chose methylene
blue because it had been used successfully and safely in other cases
and because it acts quickly.

Cawein packed his black bag and rounded up Nurse Pendergrass for the big event.
They went over to Patrick and Rachel Ritchie's house and injected each of them with
100 milligrams of methylene blue.

''Within a few minutes. the blue color was gone from their skin,"
the doctor said. "For the first time in their lives, they were pink.
They were delighted."

"They changed colors!" remembered Pendergrass.
"It was really something exciting to see."

The doctor gave each blue family a supply of methylene blue tablets to take as a
daily pill. The drug's effects are temporary, as methylene blue is normally excreted
in the urine. One day, one of the older mountain men cornered the doctor.
"I can see that old blue running out of my skin," he confided.

Before Cawein ended his study of the blue people, he returned to the mountains to
patch together the long and twisted journey of Martin Fugate's recessive gene.
From a history of Perry County and some Fugate family Bibles listing ancestors,
Cawein has constructed a fairly complete story.

Martin Fugate was a French orphan who emigrated to Kentucky in 1820 to claim a land
grant on the wilderness banks of Troublesome Creek. No mention of his skin color
is made in the early histories of the area, but family lore has it that
Martin himself was blue.

The odds against it were incalculable, but Martin Fugate managed to find and marry
a woman who carried the same recessive gene. Elizabeth Smith, apparently, was as
pale-skinned as the mountain laurel that blooms every spring around the creek hollows.

Martin and Elizabeth set up housekeeping on the banks of Troublesome and began a
family. Of their seven children, four were reported to be blue.

The clan kept multiplying. Fugates married other Fugates. Sometimes they married
first cousins. And they married the people who lived closest to them, the Combses,
Smiths, Ritchies, and Stacys. All lived in isolation from the world, bunched in log
cabins up and down the hollows, and so it was only natural that a boy married the
girl next door, even if she had the same last name.

"When they settled this country back then, there was no roads. It was hard to get
out, so they intermarried," says Dennis Stacy, a 51-year-old coal miner and amateur
genealogist who has filled a loose-leaf notebook with the laboriously traced
blood lines of several local families.

Stacy counts Fugate blood in his own veins.
"If you'll notice," he observes, tracing lines on his family's chart,
which lists his mother's and his father's great grandfather
as Henley Fugate, "I'm kin to myself."

The railroad didn't come through eastern Kentucky until the coal mines were
developed around 1912, and it took another 30 or 40 years to lay down
roads along the local creeks.

Martin and Elizabeth Fugate's
blue children multiplied in this natural isolation tank.
The marriage of one of their blue boys,
Zachariah, to his mother's sister
[Inserted NOTE: this remark is an error;
the Zachariah who married Elizabeth's sister
was the son of Martin &Mary(Wells) Fugate and
NOT the son of Martin &Elizabeth(Smith) Fugate!]

triggered the line of succession that would result in the birth,
more than 100 years later, of Benjy Stacy.

When Benjy was born with purple skin,
his relatives told the perplexed doctors about his great-grandmother
Luna Fugate. One relative describes her as "blue all over,"
and another calls Luna "the bluest woman I ever saw."

Luna's father, Levy Fugate, was one of Zachariah Fugate's sons.
[Inserted NOTE: this remark is an error;
Levy was the son of Martin &Elizabeth(Smith) Fugate.]

Levy married a Ritchie girl and bought 200 acres of rolling land
along Ball Creek. The couple had eight children, including Luna.

A fellow by the name of John E. Stacy spotted Luna at Sunday services of the
Old Regular Baptist Church back before the century turned. Stacy courted her,
married her, and moved over from Troublesome Creek to make a living in timber
on her daddy's land.

Luna has been dead nearly 20 years now, but her widower survives. John Stacy. still
lives on Lick Branch of Ball Creek. His two room log cabin sits in the middle of
Laurel Fork Hollow. Luna is buried at the top of the hollow. Stacy's son has built
a modern house next door, but the old logger won't hear of leaving the cabin he built
with timber he personally cut and hewed for Luna and their 13 children.

Stacy recalls that his father-in-law, Levy Fugate, was "part of the family that showed
blue. All them old fellers way back then was blue. One of 'em I remember seeing him
when I was just a boy Blue Anze, they called him. Most of them old people went by
that name the blue Fugates. It run in that generation who lived up and down Ball [Creek]."

"They looked like anybody else, 'cept they had the blue color," Stacy says, sitting
in a chair in his plaid flannel shirt and suspenders, next to a cardboard box where
a small black piglet, kept as a pet, is squealing for his bottle.
"I couldn't tell you what caused it."

The only thing Stacy can't or won't remember is that his wife Luna was blue.
When asked ahout it, he shakes his head and stares steadfastly ahead.
It would be hard to doubt this gracious man except that you can't find
another person who knew Luna who doesn't remember her as being blue.

"The bluest Fugates I ever saw was Luna and her kin,"
says Carrie Lee Kilburn,
a nurse who works at the rural medical center called Homeplace Clinic.
"Luna was bluish all over.
Her lips were as dark as a bruise.
She was as blue a woman as I ever saw."

Luna Stacy possessed the good health common to the blue people, bearing at least
13 children before she died at 84. The clinic doctors only saw her a few times in
her life and never for anything serious.

As coal mining and the railroads brought progress to Kentucky, the blue Fugates started
moving out of their communities and marrying other people. The strain of inherited
blue began to disappear as the recessive gene spread to families where
it was unlikely to be paired with a similar gene.

Benjy Stacy
is one of the last of the blue Fugates.

With Fugate blood on both his mother's and his father's side, the boy could have
received genes for the enzyme deficiency from either direction. Because the boy was
intensely blue at birth but then recovered his normal skin tones, Benjy is assumed
to have inherlted only one gene for the condition. Such people tend to be very blue
only at birth, probably because newborns normally have smaller amounts of diaphorase.
The enzyme eventually builds to normal levels in most children and to almost normal
levels in those like Benjy, who carry one gene.

Hilda Stacy (nee Godsey) is fiercely protective of her son. She gets upset at all
the talk of inbreeding among the Fugates. One of the supermarket tabloids once sent
a reporter to find out about the blue people, and she was distressed with his
preoccupation with intermarriages.

She and her husband Alva have a strong sense of family.
They sing in the Stacy Family Gospel Band and have provided their children with a
beautiful home and a menagerie of pets, including horses.

"Everyone around here knows about the blue Fugates," says Hilda Stacy who, at 26,
looks more like a sister than a mother to her children. "It's common. It's nothing.''

Cawein and his colleagues published their research on hereditary diaphorase
deficiency in the Archives of Internal Medicine (April, 1964) in 1964. He hasn't
studied the condition for years. Even so, Cawein still gets calls for advice. One
came from a blue Flugate who'd joined the Army and been sent to Panama, where his
son was born bright blue. Cawein advised giving the child methylene blue and not
worrying about it. Note: In this instance the reason for cyanosis was not
methemoglobinemia but Rh incompatibility. This information supplied by
John Graves whose uncle was the father of the child.

The doctor was recently approached by the producers of the television show
"That's Incredible." They wanted to parade the blue people across the screen in their
weekly display of human oddities. Cawein would have no part of it, and he related
with glee the news that a film crew sent to Kentucky from Hollywood fled the
"two mean dogs in every front yard" without any film. Cawein cheers their bad luck
not out of malice but out of a deep respect for the blue people of Troublesome Creek.

"They were poor people,"
concurs Nurse Pendergrass,
"but they were good."

Cawein, Madison, et. al.
"Hereditary diaphorase deficiency and methemoglobinemia".
Archives of Internal Medicine, April, 1964.

Scott, E.M.
"The relation of diaphorase of human erythrocytes
to inheritance of methemolglobinemia",
Journal of Clinical Investigation, 39, 1960.

Cawein, Madison and E.J. Lappat,
"Hereditary Methemoglobinemia" in Hemoglobin,
Its Precursors and Metabolites, ed. by F. William Sunderman,
J.B. Lippincott Co., Philadelphia PA, 1964.

The above is an April 2000 adaption of the article online at
maintained by Robert J. Huskey and last updated on April 5, 1999.

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